Endocrine Abstracts

BackgroundAdrenal crisis (AC) is a life threatening medical situation caused by an absolute or relative cortisol deficiency. A biological predisposition may be of importance, because some patients never experience an AC, whereas others are admitted repeatedly to the hospital for an AC. Differences in cortisol pharmacokinetics (PK) and/or pharmacodynamics (PD) may underlie this vulnerability.ObjectiveTo study ...

Background: Nutrition is essential in achieving maximal treatment success after bariatric surgery, and is simultaneously beneficial for avoiding long-term complications. Dietary protein could have an important role, because of its positive effects on preservation of muscle mass and induction of satiety in non-bariatric subjects. Therefore, we investigated the effects of dietary protein, assessed by amino acid composition, on satiety, hunger and gastrointestinal hormones after ...

Background: Early diagnosis and treatment of high blood pressure (BP) and high cholesterol is important to reduce cardiovascular mortality risk.Methods: We assessed actual BP and LDL-cholesterol (LDL-C) levels in 88,029 participants (36,122 men), aged 18-80 yrs, without diabetes, from the Dutch Lifelines Cohort study. Participants were categorized according to degree of obesity (normal weight, overweight, obese) and age decade group. BP measurement was r...

Aim: We assessed in both men and women within different BMI- and age classes the prevalence of MetS and its individual components, since these specific estimates obtained simultaneously in a large western European population are lacking. Secondly, we measured as well how age-specific blood pressure (BP) cut-offs affect the prevalence of elevated BP and MetS.Methods: Data of 74 531 western European participants, aged 18–79 years, were obtained from t...

Context: Transsphenoidal surgery (TSS) is the primary treatment of choice in acromegaly. It is important to identify patients in whom surgical cure is not attainable at an early stage, both to inform patients on expected treatment outcome and to select those who are more likely to need additional therapy.Objective: To identify predictors for remission and relapse after TSS in acromegaly.Design: Retrospective study in three large te...

Background: The clustering of metabolic and cardiovascular risk factors is known as the metabolic syndrome (MetS). Lifestyle factors like smoking may contribute to the differences in prevalence of the MetS. The aim of this study was to examine the association between smoking and the MetS and its components in different BMI classes.Methods: The present cross-sectional evaluation comprised 24 762 men and 35 558 women, participating in the LifeLines Cohort ...

Background: Transsphenoidal surgery (TSS) is the primary treatment of choice in acromegaly. Previous research succeeded to some extent in predicting remission after TSS. However, it was based mainly on clinical and radiological data, lacking histopathological evaluation.Objective: To produce a clinicopathological prediction model for remission after TSS for acromegaly, enabling clinicians to better inform patients on expected treatment outcome.<p cla...

Context: Roux-en-Y Gastric bypass (RYGB) is an effective way to induce sustainable weight loss. This operation can be complicated by late dumping, also known as postgastric bypass hyperinsulinemic hypoglycemia. Much is still unknown on its prevalence and its pathophysiology.Objective: To study the prevalence and the main driving mechanisms behind the occurrence of hypoglycemia after a mixed meal tolerance test (MMTT) in patients with primary RYGB. Design...

Introduction: The endocrinologist is confronted with an increasingly large population of postbariatric patients who present with endocrine problems. One of these is early dumping, a complication that may be the result of increased entero-endocrine activity. To address the prevalence of early dumping and to gain further insight into its pathophysiology, we performed a Mixed Meal Tolerance Test (MMTT) in a random sample of patients after Roux-en-Y gastric bypass (RYGB).<p cl...

Background: Patients with secondary adrenal insufficiency show increased risk of cardiovascular disease. Higher doses of glucocorticoid replacement are related to an unfavourable metabolic profile. In the absence of randomized controlled trials assessing the effect of hydrocortisone dose on haemodynamics and blood pressure regulation, we determined effects of a higher vs a lower glucocorticoid replacement dose on blood pressure, the renin-angiotensin-aldosterone system (RAAS) ...